Commas are used to separate “items in a series,” which means a list. The lists can be simple or complex. It’s best to look at examples.
I need eggs, butter, cheese, and flour.
This is a simple list of nouns, easy to separate with commas. The first item of the series is eggs.
I need to buy gas, pick up the kids from soccer, make dinner, and pay bills.
Each item in this series is a verb phrase (a phrase that starts with a phrase). The first item is buy gas.
I’m going to print the reports, Dave is running for office, and Jill went home early.
Each item in this series is a complete sentence, but put together like this, it’s not a run-on sentence. The first item in the series is I’m going to print the reports.
The Oxford comma is a matter of debate. This is the comma before the and in a series. The Associated Press style is to not use it. Pretty much everyone else does.
My personal preference is to not use it when the items in a series are one-word items and then use it all other times. So in the above examples, I would omit the Oxford comma in the first sentence and keep it in the rest. But this may be too eccentric for practical use.
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